Degradation of endogenous bacterial cell wall polymers by the muralytic enzyme mutanolysin prevents hepatobiliary injury in genetically susceptible rats with experimental intestinal bacterial overgrowth.

Jejunal self-filling blind loops with subsequent small bowel bacterial overgrowth (SBBO) induce hepatobiliary injury in genetically susceptible Lewis rats. Lesions consist of portal tract inflammation, bile duct proliferation, and destruction. To determine the pathogenesis of SBBO-induced hepatobili...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Lichtman, S N, Okoruwa, E E, Keku, J, Schwab, J H, Sartor, R B
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC443175/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1401067/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115996
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