Modulation of airway inflammation in cystic fibrosis. In vivo suppression of interleukin-8 levels on the respiratory epithelial surface by aerosolization of recombinant secretory leukoprotease inhibitor.

Based on the knowledge that neutrophil elastase (NE) in cystic fibrosis (CF) epithelial lining fluid (ELF) can induce human bronchial epithelial cells to express the gene for interleukin 8 (IL-8), an 8.5-kD neutrophil chemoattractant, we have evaluated CF ELF for the presence of IL-8, and investigat...

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Pubblicato in:	J Clin Invest
Autori principali:	McElvaney, N G, Nakamura, H, Birrer, P, Hébert, C A, Wong, W L, Alphonso, M, Baker, J B, Catalano, M A, Crystal, R G
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1992
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC443173/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1357002/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115994
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