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Inhibition of STAT3, FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer

Cancer stem cells (CSCs) are responsible for aggressive tumor growth, metastasis and therapy resistance. In this study, we evaluated the effects of Shikonin (Shk) on breast cancer and found its anti-CSC potential. Shk treatment decreased the expression of various epithelial to mesenchymal transition...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Thakur, Ravi, Trivedi, Rachana, Rastogi, Namrata, Singh, Manisha, Mishra, Durga Prasad
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4431480/
https://ncbi.nlm.nih.gov/pubmed/25973915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep10194
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