Marine lipopeptide Iturin A inhibits Akt mediated GSK3β and FoxO3a signaling and triggers apoptosis in breast cancer

Akt kinase is a critical component of the PI3K/Akt signaling pathway, which is frequently over expressed in human cancers including breast. Therapeutic regimens for inhibiting breast cancer with aberrant Akt activity are essential. Here, we evaluated antitumor effect of a marine bacteria derived lip...

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Vydáno v:Sci Rep
Hlavní autoři: Dey, Goutam, Bharti, Rashmi, Dhanarajan, Gunaseelan, Das, Subhasis, Dey, Kaushik Kumar, Kumar, B N Prashanth, Sen, Ramkrishna, Mandal, Mahitosh
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4431395/
https://ncbi.nlm.nih.gov/pubmed/25974307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep10316
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