Vascular smooth muscle cell hypertrophy vs. hyperplasia. Autocrine transforming growth factor-beta 1 expression determines growth response to angiotensin II.

Recent observations in our laboratory suggest that angiotensin II (Ang II) is a bifunctional vascular smooth muscle cell (VSMC) growth modulator capable of inducing hypertrophy or inhibiting mitogen-stimulated DNA synthesis. Because transforming growth factor-beta 1 (TGF beta 1) has similar bifuncti...

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Vydáno v:	J Clin Invest
Hlavní autoři:	Gibbons, G H, Pratt, R E, Dzau, V J
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Clinical Investigation 1992
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC443121/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1644917/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115881
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