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Blockade of cardiac sodium channels. Competition between the permeant ion and antiarrhythmic drugs.
A number of basic and clinical studies suggest that elevation of external sodium concentrations, [Na]o, may reverse the cardiotoxic effect of local anesthetic-class drugs. The mechanisms of reversal are uncertain. The blocking action of lidocaine and disopyramide were studied over a range of [Na]o....
Enregistré dans:
| Publié dans: | J Clin Invest |
|---|---|
| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Clinical Investigation
1992
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC443111/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1322937/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115871 |
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