Molecular basis of fibrinogen Naples associated with defective thrombin binding and thrombophilia. Homozygous substitution of B beta 68 Ala----Thr.

In an abnormal fibrinogen (fibrinogen Naples) associated with congenital thrombophilia we have identified a single base substitution (G----A) in the B beta chain gene that results in an amino acid substitution of alanine by threonine at position 68 in the B beta chain of fibrinogen. The propositus a...

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Argitaratua izan da:	J Clin Invest
Egile Nagusiak:	Koopman, J, Haverkate, F, Lord, S T, Grimbergen, J, Mannucci, P M
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	American Society for Clinical Investigation 1992
Gaiak:	Research Article
Sarrera elektronikoa:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC443086/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1634610/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115841
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