Spatially Discordant Alternans and Arrhythmias in Tachypacing-Induced Cardiac Myopathy in Transgenic LQT1 Rabbits: The Importance of I(Ks) and Ca(2+) Cycling

BACKGROUND: Remodeling of cardiac repolarizing currents, such as the downregulation of slowly activating K(+) channels (I(Ks)), could underlie ventricular fibrillation (VF) in heart failure (HF). We evaluated the role of I (ks) remodeling in VF susceptibility using a tachypacing HF model of transgen...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Lau, Emily, Kossidas, Konstantinos, Kim, Tae Yun, Kunitomo, Yukiko, Ziv, Ohad, Zhen, Song, Taylor, Chantel, Schofield, Lorraine, Yammine, Joe, Liu, Gongxin, Peng, Xuwen, Qu, Zhilin, Koren, Gideon, Choi, Bum-Rak
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4430457/
https://ncbi.nlm.nih.gov/pubmed/25970695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0122754
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