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Mechanisms of Nifedipine-Downregulated CD40L/sCD40L Signaling in Collagen Stimulated Human Platelets

The platelet-derived soluble CD40L (sCD40L) release plays a critical role in the development of atherosclerosis. Nifedipine, a dihydropyridine-based L-type calcium channel blocker (CCB), has been reported to have an anti-atherosclerotic effect beyond its blood pressure-lowering effect, but the molec...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Chen, Tso-Hsiao, Shih, Ching-Yu, Hsu, Wen-Lin, Chou, Tz-Chong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4430314/
https://ncbi.nlm.nih.gov/pubmed/25970603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0127054
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