Factor VIII-East Hartford (arginine 1689 to cysteine) has procoagulant activity when separated from von Willebrand factor.

Factor VIII East Hartford (FVIII-EH) procoagulant activity is reduced because the substitution of cysteine for arginine 1689 abolishes an essential Factor VIII light chain thrombin cleavage site. Incubation of FVIII-EH plasma with penicillamine or DTT causes a five- to sixfold increase in FVIII-EH V...

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Pubblicato in:	J Clin Invest
Autori principali:	Aly, A M, Hoyer, L W
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1992
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC443006/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1569181/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115726
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