Isoform-specific regulation of platelet-derived growth factor activity and binding in osteoblast-enriched cultures from fetal rat bone.

In osteoblast-enriched cultures from fetal rat bone, the A-chain homodimer of platelet-derived growth factor (PDGF-AA) is less potent than the PDGF isoforms containing B chain subunits (PDGF-AB and PDGF-BB), but normal osteoblasts appear to synthesize only PDGF-A subunit mRNA and polypeptide. Howeve...

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Publié dans:	J Clin Invest
Auteurs principaux:	Centrella, M, McCarthy, T L, Kusmik, W F, Canalis, E
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Clinical Investigation 1992
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC442963/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1313443/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115687
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