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Understanding the foundations of the structural similarities between marketed drugs and endogenous human metabolites

Background: A recent comparison showed the extensive similarities between the structural properties of metabolites in the reconstructed human metabolic network (“endogenites”) and those of successful, marketed drugs (“drugs”). Results: Clustering indicated the related but differential population of...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: O'Hagan, Steve, Kell, Douglas B.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4429554/
https://ncbi.nlm.nih.gov/pubmed/26029108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2015.00105
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