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Challenging muscle homeostasis uncovers novel chaperone interactions in Caenorhabditis elegans

Proteome stability is central to cellular function and the lifespan of an organism. This is apparent in muscle cells, where incorrect folding and assembly of the sarcomere contributes to disease and aging. Apart from the myosin-assembly factor UNC-45, the complete network of chaperones involved in a...

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Veröffentlicht in:Front Mol Biosci
Hauptverfasser: Frumkin, Anna, Dror, Shiran, Pokrzywa, Wojciech, Bar-Lavan, Yael, Karady, Ido, Hoppe, Thorsten, Ben-Zvi, Anat
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2014
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4428482/
https://ncbi.nlm.nih.gov/pubmed/25988162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2014.00021
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