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A Transgenic Probiotic Secreting a Parasite Immunomodulator for Site-Directed Treatment of Gut Inflammation

New treatment strategies for inflammatory bowel disease are needed and parasitic nematode infections or application of helminth components improve clinical and experimental gut inflammation. We genetically modified the probiotic bacterium Escherichia coli Nissle 1917 to secrete the powerful nematode...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Whelan, Rose A, Rausch, Sebastian, Ebner, Friederike, Günzel, Dorothee, Richter, Jan F, Hering, Nina A, Schulzke, Jörg-Dieter, Kühl, Anja A, Keles, Ahmed, Janczyk, Pawel, Nöckler, Karsten, Wieler, Lothar H, Hartmann, Susanne
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4428401/
https://ncbi.nlm.nih.gov/pubmed/24985163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.125
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