Effects of chain length on the immunogenicity in rabbits of group B Streptococcus type III oligosaccharide-tetanus toxoid conjugates.

One method to improve the immunogenicity of polysaccharide antigens is the covalent coupling of the native polysaccharide or a derivative oligosaccharide to a carrier protein. In general, T cell-dependent properties are enhanced in conjugates of smaller saccharides, but a conformational epitope of t...

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Bibliographic Details
Main Authors: Paoletti, L C, Kasper, D L, Michon, F, DiFabio, J, Jennings, H J, Tosteson, T D, Wessels, M R
Format: Artigo
Language:Inglês
Published: 1992
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC442838/
https://ncbi.nlm.nih.gov/pubmed/1729272
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