Effects of chain length on the immunogenicity in rabbits of group B Streptococcus type III oligosaccharide-tetanus toxoid conjugates.

One method to improve the immunogenicity of polysaccharide antigens is the covalent coupling of the native polysaccharide or a derivative oligosaccharide to a carrier protein. In general, T cell-dependent properties are enhanced in conjugates of smaller saccharides, but a conformational epitope of t...

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Pubblicato in:	J Clin Invest
Autori principali:	Paoletti, L C, Kasper, D L, Michon, F, DiFabio, J, Jennings, H J, Tosteson, T D, Wessels, M R
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1992
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC442838/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1729272/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115564
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