A point mutation in the extracellular domain of KIT promotes tumorigenesis of mast cells via ligand-independent auto-dimerization

Mutations in the juxtamembrane and tyrosine kinase domains of the KIT receptor have been implicated in several cancers and are known to promote tumorigenesis. However, the pathophysiological manifestations of mutations in the extracellular domain remain unknown. In this study, we examined the impact...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Amagai, Yosuke, Matsuda, Akira, Jung, Kyungsook, Oida, Kumiko, Jang, Hyosun, Ishizaka, Saori, Matsuda, Hiroshi, Tanaka, Akane
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4428273/
https://ncbi.nlm.nih.gov/pubmed/25965812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09775
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