L-428 nodular sclerosing Hodgkin's cell secretes a unique transforming growth factor-beta active at physiologic pH.

Nodular sclerosing Hodgkin's disease is characterized by dense collagen fibrosis. Although transforming growth factor-beta (TGF-beta) is an important bifunctional growth factor for fibroblasts and is stored and released by many cells, it requires acidification to pH 2.0-3.0 before it becomes a biolo...

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Bibliografske podrobnosti

izdano v:	J Clin Invest
Principais autores:	Newcom, S R, Kadin, M E, Ansari, A A, Diehl, V
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Clinical Investigation 1988
Teme:	Research Article
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC442772/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2904450/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI113810
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