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IRGM governs the core autophagy machinery to conduct antimicrobial defense
IRGM, encoded by a uniquely human gene conferring risk for inflammatory diseases, affects autophagy through a hitherto unknown mechanism. Here we show how IRGM controls autophagy. IRGM interacts with ULK1 and Beclin 1 and promotes their co-assembly thus governing the formation of autophagy initiatio...
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| Gepubliceerd in: | Mol Cell |
|---|---|
| Hoofdauteurs: | , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2015
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4427528/ https://ncbi.nlm.nih.gov/pubmed/25891078 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.03.020 |
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