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Shikonin Suppresses Skin Carcinogenesis via Inhibiting Cell Proliferation
The M2 isoform of pyruvate kinase M2 (PKM2) has been shown to be up-regulated in human skin cancers. To test whether PKM2 may be a target for chemoprevention, shikonin, a natural product from the root of Lithospermum erythrorhizon and a specific inhibitor of PKM2, was used in a chemically-induced mo...
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| 發表在: | PLoS One |
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| Main Authors: | , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Public Library of Science
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4427333/ https://ncbi.nlm.nih.gov/pubmed/25961580 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0126459 |
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