Suberoylanilide hydroxamic acid (SAHA) reverses chemoresistance in head and neck cancer cells by targeting cancer stem cells via the downregulation of nanog

Acquisition of chemoresistance and metastatic phenotype are the major causes of treatment failure and mortality in head and neck squamous cell carcinoma (HNSCC) patients. Histone deacetylases (HDACs) have been shown to be overexpressed in many tumor types and directly linked to poor prognosis. In th...

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Bibliografiske detaljer
Udgivet i:Genes Cancer
Main Authors: Kumar, Bhavna, Yadav, Arti, Lang, James C., Teknos, Theodoros N., Kumar, Pawan
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4426953/
https://ncbi.nlm.nih.gov/pubmed/26000099
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