Suberoylanilide hydroxamic acid (SAHA) reverses chemoresistance in head and neck cancer cells by targeting cancer stem cells via the downregulation of nanog

Acquisition of chemoresistance and metastatic phenotype are the major causes of treatment failure and mortality in head and neck squamous cell carcinoma (HNSCC) patients. Histone deacetylases (HDACs) have been shown to be overexpressed in many tumor types and directly linked to poor prognosis. In th...

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Detalhes bibliográficos
Publicado no:Genes Cancer
Main Authors: Kumar, Bhavna, Yadav, Arti, Lang, James C., Teknos, Theodoros N., Kumar, Pawan
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4426953/
https://ncbi.nlm.nih.gov/pubmed/26000099
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