Genome-wide Computational Analysis Reveals Cardiomyocyte-specific Transcriptional Cis-regulatory Motifs That Enable Efficient Cardiac Gene Therapy

Gene therapy is a promising emerging therapeutic modality for the treatment of cardiovascular diseases and hereditary diseases that afflict the heart. Hence, there is a need to develop robust cardiac-specific expression modules that allow for stable expression of the gene of interest in cardiomyocyt...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Rincon, Melvin Y, Sarcar, Shilpita, Danso-Abeam, Dina, Keyaerts, Marleen, Matrai, Janka, Samara-Kuko, Ermira, Acosta-Sanchez, Abel, Athanasopoulos, Takis, Dickson, George, Lahoutte, Tony, De Bleser, Pieter, VandenDriessche, Thierry, Chuah, Marinee K
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4426801/
https://ncbi.nlm.nih.gov/pubmed/25195597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.178
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