CD133-targeted Gene Transfer Into Long-term Repopulating Hematopoietic Stem Cells

Gene therapy for hematological disorders relies on the genetic modification of CD34(+) cells, a heterogeneous cell population containing about 0.01% long-term repopulating cells. Here, we show that the lentiviral vector CD133-LV, which uses a surface marker on human primitive hematopoietic stem cell...

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Bibliographic Details
Published in:Mol Ther
Main Authors: Brendel, Christian, Goebel, Benjamin, Daniela, Abriss, Brugman, Martijn, Kneissl, Sabrina, Schwäble, Joachim, Kaufmann, Kerstin B, Müller-Kuller, Uta, Kunkel, Hana, Chen-Wichmann, Linping, Abel, Tobias, Serve, Hubert, Bystrykh, Leonid, Buchholz, Christian J, Grez, Manuel
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4426797/
https://ncbi.nlm.nih.gov/pubmed/25189742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.173
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