Genetic markers in the EET metabolic pathway are associated with outcomes in patients with aneurysmal subarachnoid hemorrhage

Preclinical studies show that epoxyeicosatrienoic acids (EETs) regulate cerebrovascular tone and protect against cerebral ischemia. We investigated the relationship between polymorphic genes involved in EET biosynthesis/metabolism, cytochrome P450 (CYP) eicosanoid levels, and outcomes in 363 patient...

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Bibliografiske detaljer
Udgivet i:J Cereb Blood Flow Metab
Main Authors: Donnelly, Mark K, Conley, Yvette P, Crago, Elizabeth A, Ren, Dianxu, Sherwood, Paula R, Balzer, Jeffery R, Poloyac, Samuel M
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4426743/
https://ncbi.nlm.nih.gov/pubmed/25388680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2014.195
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