Heightened potency of human pluripotent stem cell lines created by transient BMP4 exposure

Human pluripotent stem cells (PSCs) show epiblast-type pluripotency that is maintained with ACTIVIN/FGF2 signaling. Here, we report the acquisition of a unique stem cell phenotype by both human ES cells (hESCs) and induced pluripotent stem cells (iPSCs) in response to transient (24–36 h) exposure to...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Yang, Ying, Adachi, Katsuyuki, Sheridan, Megan A., Alexenko, Andrei P., Schust, Danny J., Schulz, Laura C., Ezashi, Toshihiko, Roberts, R. Michael
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4426460/
https://ncbi.nlm.nih.gov/pubmed/25870291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1504778112
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