Pharmacokinetics and Osteogenic Potential of PEGylated NELL-1 In Vivo After Systemic Administration

Osteoporosis is a skeletal disorder attributable to an imbalance in osteoblast and osteoclast activity. NELL-1, a secretory protein that promotes osteogenesis while suppressing osteoclastic activity, holds potential as an osteoporosis therapy. Recently, we demonstrated that PEGylation of NELL-1 sign...

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Detalhes bibliográficos
Publicado no:Biomaterials
Main Authors: Kwak, Jin Hee, Zhang, Yulong, Park, Juyoung, Chen, Eric, Shen, Jia, Chawan, Chirag, Tanjaya, Justine, Lee, Soonchul, Zhang, Xinli, Wu, Benjamin, Ting, Kang, Soo, Chia
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4426150/
https://ncbi.nlm.nih.gov/pubmed/25913252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2015.03.063
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