Transporter-mediated L-glutamate elimination from cerebrospinal fluid: possible involvement of excitatory amino acid transporters expressed in ependymal cells and choroid plexus epithelial cells

BACKGROUND: L-Glutamate (L-Glu) is the major excitatory neurotransmitter in the CNS, and its level in cerebrospinal fluid (CSF) is reported to be increased in neuroexcitatory diseases such as epilepsy. Since L-Glu concentration in the CSF is reported to be lower than that in plasma, it has been prop...

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Published in:Fluids Barriers CNS
Main Authors: Akanuma, Shin-ichi, Sakurai, Tatsuhiko, Tachikawa, Masanori, Kubo, Yoshiyuki, Hosoya, Ken-ichi
Format: Artigo
Language:Inglês
Published: BioMed Central 2015
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4425921/
https://ncbi.nlm.nih.gov/pubmed/25925580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12987-015-0006-x
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