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Distinguishing low frequency mutations from RT-PCR and sequence errors in viral deep sequencing data
BACKGROUND: RNA viruses have high mutation rates and exist within their hosts as large, complex and heterogeneous populations, comprising a spectrum of related but non-identical genome sequences. Next generation sequencing is revolutionising the study of viral populations by enabling the ultra deep...
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| Publicado no: | BMC Genomics |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4425905/ https://ncbi.nlm.nih.gov/pubmed/25886445 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-015-1456-x |
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