Interleukin-1 Receptor Antagonist Reduces Neonatal Lipopolysaccharide-Induced Long-Lasting Neurobehavioral Deficits and Dopaminergic Neuronal Injury in Adult Rats

Our previous study showed that a single lipopolysaccharide (LPS) treatment to neonatal rats could induce a long-lasting neuroinflammatory response and dopaminergic system injury late in life. This is evidenced by a sustained activation of microglia and elevated interleukin-1β (IL-1β) levels, as well...

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Publicado en:Int J Mol Sci
Autores principales: Pang, Yi, Tien, Lu-Tai, Zhu, Hobart, Shen, Juying, Wright, Camilla F., Jones, Tembra K., Mamoon, Samir A., Bhatt, Abhay J., Cai, Zhengwei, Fan, Lir-Wan
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4425101/
https://ncbi.nlm.nih.gov/pubmed/25898410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms16048635
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