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Clinical trialist perspectives on the ethics of adaptive clinical trials: a mixed-methods analysis

BACKGROUND: In an adaptive clinical trial (ACT), key trial characteristics may be altered during the course of the trial according to predefined rules in response to information that accumulates within the trial itself. In addition to having distinguishing scientific features, adaptive trials also m...

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Опубликовано в: :BMC Med Ethics
Главные авторы: Legocki, Laurie J, Meurer, William J, Frederiksen, Shirley, Lewis, Roger J, Durkalski, Valerie L, Berry, Donald A, Barsan, William G, Fetters, Michael D
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2015
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4424427/
https://ncbi.nlm.nih.gov/pubmed/25933921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12910-015-0022-z
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