Glycan Motif Profiling Reveals Plasma Sialyl-Lewis X Elevations in Pancreatic Cancers That Are Negative for Sialyl-Lewis A

The sialyl-Lewis A (sLeA) glycan forms the basis of the CA19–9 assay and is the current best biomarker for pancreatic cancer, but because it is not elevated in ∼25% of pancreatic cancers, it is not useful for early diagnosis. We hypothesized that sLeA-low tumors secrete glycans that are related to s...

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Sparad:
Bibliografiska uppgifter
I publikationen:Mol Cell Proteomics
Huvudupphovsmän: Tang, Huiyuan, Singh, Sudhir, Partyka, Katie, Kletter, Doron, Hsueh, Peter, Yadav, Jessica, Ensink, Elliot, Bern, Marshall, Hostetter, Galen, Hartman, Douglas, Huang, Ying, Brand, Randall E., Haab, Brian B.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The American Society for Biochemistry and Molecular Biology 2015
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4424402/
https://ncbi.nlm.nih.gov/pubmed/25733690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M114.047837
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