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Sirtuin Inhibition Induces Apoptosis-like Changes in Platelets and Thrombocytopenia
Sirtuins are evolutionarily conserved NAD(+)-dependent acetyl-lysine deacetylases that belong to class III type histone deacetylases. In humans, seven sirtuin isoforms (Sirt1 to Sirt7) have been identified. Sirtinol, a cell-permeable lactone ring derived from naphthol, is a dual Sirt1/Sirt2 inhibito...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4424360/ https://ncbi.nlm.nih.gov/pubmed/25829495 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.615948 |
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