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Structural mechanism of integrin inactivation by filamin
The activation of heterodimeric (α/β) integrin is crucial for regulating cell adhesion. Binding of talin to the cytoplasmic face of integrin activates the receptor, but how integrin is properly maintained in resting state to counterbalance its activation for regulating adhesion dynamics remains obsc...
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| Publicado no: | Nat Struct Mol Biol |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4424056/ https://ncbi.nlm.nih.gov/pubmed/25849143 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2999 |
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