ALDH1B1 Is Crucial for Colon Tumorigenesis by Modulating Wnt/β-Catenin, Notch and PI3K/Akt Signaling Pathways

In the normal human colon, aldehyde dehydrogenase 1B1 (ALDH1B1) is expressed only at the crypt base, along with stem cells. It is also highly expressed in the human colonic adenocarcinomas. This pattern of expression corresponds closely to that observed for Wnt/β-catenin signaling activity. The pres...

詳細記述

保存先:
書誌詳細
出版年:PLoS One
主要な著者: Singh, Surendra, Arcaroli, John, Chen, Ying, Thompson, David C., Messersmith, Wells, Jimeno, Antonio, Vasiliou, Vasilis
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2015
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4423958/
https://ncbi.nlm.nih.gov/pubmed/25950950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0121648
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