Z-type alpha 1-antitrypsin is less competent than M1-type alpha 1-antitrypsin as an inhibitor of neutrophil elastase.

Alpha 1-antitrypsin (alpha 1AT) deficiency resulting from homozygous inheritance of the Z-type alpha 1AT gene is associated with serum alpha 1AT levels of less than 50 mg/dl and the development of emphysema in the third to fourth decades. Despite the overwhelming evidence that the emphysema of PiZZ...

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Опубликовано в::	J Clin Invest
Главные авторы:	Ogushi, F, Fells, G A, Hubbard, R C, Straus, S D, Crystal, R G
Формат:	Artigo
Язык:	Inglês
Опубликовано:	American Society for Clinical Investigation 1987
Предметы:	Research Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC442392/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3500183/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI113214
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