Oxidants spontaneously released by alveolar macrophages of cigarette smokers can inactivate the active site of alpha 1-antitrypsin, rendering it ineffective as an inhibitor of neutrophil elastase.

Current concepts relating to the pathogenesis of emphysema associated with cigarette smoking is that an imbalance exists within the lower respiratory tract between neutrophil elastase and the local anti-neutrophil elastase screen, enabling uninhibited neutrophil elastase to destroy the alveolar stru...

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Manylion Llyfryddiaeth

Cyhoeddwyd yn:	J Clin Invest
Prif Awduron:	Hubbard, R C, Ogushi, F, Fells, G A, Cantin, A M, Jallat, S, Courtney, M, Crystal, R G
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	American Society for Clinical Investigation 1987
Pynciau:	Research Article
Mynediad Ar-lein:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC442382/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2824559/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI113204
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