Unusually large von Willebrand factor multimers increase adhesion of sickle erythrocytes to human endothelial cells under controlled flow.

The interactions of normal erythrocytes and erythrocytes from patients having hemoglobin S hemoglobinopathies with normal human endothelial cells (EC) were investigated under flow conditions. When EC supernatant, containing 2.8-11.0 U/dl of von Willebrand factor (vWF) antigen and vWF multimeric form...

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Pubblicato in:	J Clin Invest
Autori principali:	Wick, T M, Moake, J L, Udden, M M, Eskin, S G, Sears, D A, McIntire, L V
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1987
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC442320/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3497953/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI113151
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