Identification and characterization of phosphodiesterases that specifically degrade 3′3′-cyclic GMP-AMP

Cyclic dinucleotides act as intracellular second messengers, modulating a variety of cellular activities including innate immune activation. Although phosphodiesterases (PDEs) hydrolyzing c-di-GMP and c-di-AMP have been identified, no PDEs for cGAMPs have been reported. Here we identified the first...

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Publicat a:Cell Res
Autors principals: Gao, Juyi, Tao, Jianli, Liang, Weili, Zhao, Meng, Du, Xiaoxia, Cui, Shan, Duan, Haifeng, Kan, Biao, Su, Xiaodong, Jiang, Zhengfan
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4423081/
https://ncbi.nlm.nih.gov/pubmed/25837739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2015.40
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