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Kinesin-1 Motors Can Circumvent Permanent Roadblocks by Side-Shifting to Neighboring Protofilaments

Obstacles on the surface of microtubules can lead to defective cargo transport, proposed to play a role in neurological diseases such as Alzheimer’s. However, little is known about how motor proteins, which follow individual microtubule protofilaments (such as kinesin-1), deal with obstacles on the...

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Библиографические подробности
Опубликовано в: :Biophys J
Главные авторы: Schneider, René, Korten, Till, Walter, Wilhelm J., Diez, Stefan
Формат: Artigo
Язык:Inglês
Опубликовано: The Biophysical Society 2015
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4423065/
https://ncbi.nlm.nih.gov/pubmed/25954882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.03.048
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