LPS Increases 5-LO Expression on Monocytes via an Activation of Akt-Sp1/NF-κB Pathways

5-Lipoxygenase (5-LO) plays a pivotal role in the progression of atherosclerosis. Therefore, this study investigated the molecular mechanisms involved in 5-LO expression on monocytes induced by LPS. Stimulation of THP-1 monocytes with LPS (0~3 µg/ml) increased 5-LO promoter activity and 5-LO protein...

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Bibliographic Details
Published in:Korean J Physiol Pharmacol
Main Authors: Lee, Seung Jin, Seo, Kyo Won, Kim, Chi Dae
Format: Artigo
Language:Inglês
Published: The Korean Physiological Society and The Korean Society of Pharmacology 2015
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4422967/
https://ncbi.nlm.nih.gov/pubmed/25954132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4196/kjpp.2015.19.3.263
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