Methylation and its role in the disposition of tanshinol, a cardiovascular carboxylic catechol from Salvia miltiorrhiza roots (Danshen)

AIM: Tanshinol is an important catechol in the antianginal herb Salvia miltiorrhiza roots (Danshen). This study aimed to characterize tanshinol methylation. METHODS: Metabolites of tanshinol were analyzed by liquid chromatography/mass spectrometry. Metabolism was assessed in vitro with rat and human...

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Detalhes bibliográficos
Publicado no:Acta Pharmacol Sin
Main Authors: Tian, Dan-dan, Jia, Wei-wei, Liu, Xin-wei, Wang, Dan-dan, Liu, Jun-hua, Dong, Jia-jia, Li, Li, Du, Fei-fei, Xu, Fang, Wang, Feng-qing, Sun, Yan, Huang, Yu-xing, Li, Mei-juan, Hu, Li-hong, Zhu, Yan, Gao, Xiu-mei, Li, Chuan, Yang, Jun-ling
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4422947/
https://ncbi.nlm.nih.gov/pubmed/25891082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2015.20
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