Immunomodulatory Protein from Ganoderma microsporum Induces Pro-Death Autophagy through Akt-mTOR-p70S6K Pathway Inhibition in Multidrug Resistant Lung Cancer Cells

Chemoresistance in cancer therapy is an unfavorable prognostic factor in non-small cell lung cancer (NSCLC). Elevation of intracellular calcium level in multidrug resistant (MDR) sublines leads to sensitization of MDR sublines to cell death. We demonstrated that a fungal protein from Ganoderma micro...

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Veröffentlicht in:PLoS One
Hauptverfasser: Chiu, Ling-Yen, Hu, Ming-E, Yang, Tsung-Ying, Hsin, I-Lun, Ko, Jiunn-Liang, Tsai, Kan-Jen, Sheu, Gwo-Tarng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4422711/
https://ncbi.nlm.nih.gov/pubmed/25946033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0125774
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