Impaired autophagy in mouse embryonic fibroblasts null for Krüppel-like Factor 4 promotes DNA damage and increases apoptosis upon serum starvation

BACKGROUND: Autophagy is a major cellular process by which cytoplasmic components such as damaged organelles and misfolded proteins are recycled. Although low levels of autophagy occur in cells under basal conditions, certain cellular stresses including nutrient depletion, DNA damage, and oxidative...

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Gepubliceerd in:Mol Cancer
Hoofdauteurs: Liu, Changchang, DeRoo, Elise P, Stecyk, Catherine, Wolsey, Margaret, Szuchnicki, Mateusz, Hagos, Engda G
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2015
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Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4422415/
https://ncbi.nlm.nih.gov/pubmed/25944097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-015-0373-6
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