Impaired autophagy in mouse embryonic fibroblasts null for Krüppel-like Factor 4 promotes DNA damage and increases apoptosis upon serum starvation

BACKGROUND: Autophagy is a major cellular process by which cytoplasmic components such as damaged organelles and misfolded proteins are recycled. Although low levels of autophagy occur in cells under basal conditions, certain cellular stresses including nutrient depletion, DNA damage, and oxidative...

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Detaylı Bibliyografya
Yayımlandı:Mol Cancer
Asıl Yazarlar: Liu, Changchang, DeRoo, Elise P, Stecyk, Catherine, Wolsey, Margaret, Szuchnicki, Mateusz, Hagos, Engda G
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2015
Konular:
Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4422415/
https://ncbi.nlm.nih.gov/pubmed/25944097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-015-0373-6
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