Mistrafficking of prenylated proteins causes retinitis pigmentosa 2

The retinitis pigmentosa 2 polypeptide (RP2) functions as a GTPase-activating protein (GAP) for ARL3 (Arf-like protein 3), a small GTPase. ARL3 is an effector of phosphodiesterase 6 Δ (PDE6D), a prenyl-binding protein and chaperone of prenylated protein in photoreceptors. Mutations in the human RP2...

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Dades bibliogràfiques
Publicat a:FASEB J
Autors principals: Zhang, Houbin, Hanke-Gogokhia, Christin, Jiang, Li, Li, Xiaobo, Wang, Pu, Gerstner, Cecilia D., Frederick, Jeanne M., Yang, Zhenglin, Baehr, Wolfgang
Format: Artigo
Idioma:Inglês
Publicat: Federation of American Societies for Experimental Biology 2015
Matèries:
Research Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4422365/
https://ncbi.nlm.nih.gov/pubmed/25422369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.14-257915
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