Essential nutrient supplementation prevents heritable metabolic disease in multigenerational intrauterine growth-restricted rats

Intrauterine growth restriction (IUGR) confers heritable alterations in DNA methylation, rendering risk of adult metabolic syndrome (MetS). Because CpG methylation is coupled to intake of essential nutrients along the one-carbon pathway, we reasoned that essential nutrient supplementation (ENS) may...

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Bibliografiske detaljer
Udgivet i:FASEB J
Main Authors: Goodspeed, Danielle, Seferovic, Maxim D., Holland, William, Mcknight, Robert A., Summers, Scott A., Branch, D. Ware, Lane, Robert H., Aagaard, Kjersti M.
Format: Artigo
Sprog:Inglês
Udgivet: Federation of American Societies for Experimental Biology 2015
Fag:
Research Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4422359/
https://ncbi.nlm.nih.gov/pubmed/25395450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.14-259614
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