Quantitative and multiplexed DNA methylation analysis using long-read single-molecule real-time bisulfite sequencing (SMRT-BS)

BACKGROUND: DNA methylation has essential roles in transcriptional regulation, imprinting, X chromosome inactivation and other cellular processes, and aberrant CpG methylation is directly involved in the pathogenesis of human imprinting disorders and many cancers. To address the need for a quantitat...

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Pubblicato in:BMC Genomics
Autori principali: Yang, Yao, Sebra, Robert, Pullman, Benjamin S, Qiao, Wanqiong, Peter, Inga, Desnick, Robert J, Geyer, C Ronald, DeCoteau, John F, Scott, Stuart A
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
Soggetti:
Methodology Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4422326/
https://ncbi.nlm.nih.gov/pubmed/25943404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-015-1572-7
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