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Killing of human melanoma cells by the membrane attack complex of human complement as a function of its molecular composition.

The efficiency of the membrane attack complex (MAC) in killing M21 melanoma cells was determined varying the molar ratio of cell-bound C9:C8. It was found that C5b-8 produced functional channels as evidenced by 86Rb release and propidium iodide uptake; cell killing occurred in the absence of C9 with...

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Publicado en:J Clin Invest
Autores principales: Martin, D E, Chiu, F J, Gigli, I, Müller-Eberhard, H J
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 1987
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Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC442222/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3597774/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI113052
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