The biological clock that measures the mitotic life-span of mouse embryo fibroblasts continues to function in the presence of simian virus 40 large tumor antigen.
Normal mammalian fibroblasts cultured in vitro undergo a limited number of divisions before entering a senescent phase in which they can be maintained for long periods but cannot be induced to divide. In rodent fibroblasts senescence can be prevented by expression of simian virus 40 large tumor anti...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1994
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44219/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8022803/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.14.6448 |
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