Lipid exposure elicits differential responses in gene expression and DNA methylation in primary human skeletal muscle cells from severely obese women

The skeletal muscle of obese individuals exhibits an impaired ability to increase the expression of genes linked with fatty acid oxidation (FAO) upon lipid exposure. The present study determined if this response could be attributed to differential DNA methylation signatures. RNA and DNA were isolate...

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Détails bibliographiques
Publié dans:Physiol Genomics
Auteurs principaux: Maples, Jill M., Brault, Jeffrey J., Shewchuk, Brian M., Witczak, Carol A., Zou, Kai, Rowland, Naomi, Hubal, Monica J., Weber, Todd M., Houmard, Joseph A.
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2015
Sujets:
Regulation of Gene Expression
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4421792/
https://ncbi.nlm.nih.gov/pubmed/25670728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.00065.2014
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