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Severe adverse effects of 5-fluorouracil in S-1 were lessened by haemodialysis due to elimination of the drug
S-1 and cisplatin are used as one of the first-line chemotherapies for gastric cancer in Japan. The plasma concentration of 5-fluorouracil (5-FU) is increased in patients with renal dysfunction because gimeracil in S-1 inhibits the degradation of 5-FU and about 50% of gimeracil is excreted in the ur...
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| Publicado no: | NDT Plus |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4421365/ https://ncbi.nlm.nih.gov/pubmed/25949315 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ndtplus/sfn195 |
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