A requirement of hydrophobic and basic amino acid residues for substrate recognition by Ca2+/calmodulin-dependent protein kinase Ia.

The substrate recognition determinants of Ca2+/calmodulin-dependent protein kinase Ia were investigated by using peptide analogues based on the amino acid sequence around Ser-9 of synapsin I. The Km and Vmax for the synthetic peptide Leu-Arg-Arg-Arg-Leu-Ser-Asp-Ala-Asn-Phe are 3.9 microM and 18.5 mu...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Lee, J C, Kwon, Y G, Lawrence, D S, Edelman, A M
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1994
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44212/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8022798/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.14.6413
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